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  • Molecular assay reagents intended to identify mutations in the vitamin K epoxide reductase complex, subunit 1 gene, located at chromosome 16p11.2, which encodes the enzyme that is responsible for reducing vitamin K 2,3-epoxide to the enzymatically activated form. Fatal bleeding can be caused by vitamin K deficiency and by the vitamin K antagonist warfarin, and it is the product of this gene that is sensitive to warfarin. Mutations at this locus, such as the presence of the sensitive AA genotype, can be associated with a high sensitivity to the effects of warfarin; on the contrary, the presence of a GG genotype usually is associated with a high resistance to the effects of warfarin.
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