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  • Molecular assay reagents intended to identify mutations in the cytochrome P450, family 2, subfamily C, polypeptide 9 (CYP2C9) gene, located at chromosome 10q24, which encodes a member of the cytochrome P450 superfamily of enzymes. P450 cytochrome is involved in the processing of ingested drugs and synthesizing of cholesterol, steroid hormones, and lipids. Mutations at this locus have been identified in patients who have a slower rate of warfarin metabolism. Determination of the patient\'s CYP2C9 genotype may guide the choice of the initial warfarin dose, potentially reducing the period of time before the standard method of measuring the extrinsic pathway of coagulation (i.e., prothrombin time and/or the international normalized ratio [INR]) stabilizes.
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