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Molecular assay reagents intended to identify mutations in the von Hippel-Lindau tumor suppressor (VHL) gene, located at chromosome 3p26-p25, a tumor which makes a protein that is part of a complex (VCB) that targets other proteins to be broken down in the cell. This inherited genetic mutation has been identified in patients with clear cell renal cancer and Von Hippel-Lindau syndrome; it is also associated with hereditary renal cell carcinoma and polycythemia.
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