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  • Molecular assay reagents intended to identify mutations in the thiopurine S-methyltransferase (TPMT) gene, located at chromosome 6p22.3, which encodes for an enzyme that metabolizes thiopurine drugs. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals. This genetic mutation has been identified in patients with thiopurine S-methyltransferase deficiency.
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