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  • Molecular assay reagents intended to identify mutations in the iduronidase, alpha-L- (IDUA) gene, located at chromosome 4p16.3, which is involved in the hydrolysis of unsulfated alpha-L-iduronosidic linkages in dermatan sulfate; ultimately the gene is involved in breakdown of muccopolysaccarides. Mutations at this locus have been identified in patients with mucopolysaccharidosis type I (MPS1); patients may be classified according to the severity of the disease: mild, intermediate, or severe (known as Scheie\'s, Hurler-Scheie, and Hurler\'s syndromes, respectively).
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