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  • Molecular assay reagents intended to identify mutations in the coagulation factor II (thrombin) (F2) gene, located at chromosome 11p11-q12, which encodes for the protein thrombin that converts fibrinogen to fibrin. Mutations at this locus have been identified in patients with dysprothrombinemia and as a risk factor for cerebrovascular ischemic disease, deep vein thrombosis, and idiopathic portal vein thrombosis.
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