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  • Serology reagents intended to detect antibodies to vaccinia virus, a virus of the genus Orthopoxvirus that does not occur in nature (it is propagated only in the laboratory for use as an active vaccine against smallpox). Vaccinia viruses cause mild reactions in healthy persons when used as a live-virus inoculator against smallpox; vaccinia smallpox vaccine does not contain and cannot cause smallpox, but approximately one in one million individuals will develop an acute (and even fatal) response to the vaccination.
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