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  • Serology reagents intended to detect antibodies to the M protein produced by Streptococcus group A (typically Streptococcus pyogenes), a spherical bacteria of the family Streptococcaceae. Streptococcus pyogenes is one of the most important bacterial human pathogens, causing a wide range of suppurative diseases (e.g., pharyngitis, otitis media, sinusitis, endocarditis) and nonsuppurative sequelae (e.g., acute rheumatic fever). These antibodies identify specific groups of S. and may be associated with some autoimmune diseases (such as acute rheumatic fever) idiopathic mitral regurgitation, and poststreptococcal glomerulonephritis.
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