?:definition
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Clinical chemistry reagents intended to perform qualitative and/or quantitative analyses on a body fluid sample (e.g., whole blood, erythrocyte hemolysates) to determine the thiamine (vitamin B1) status by measuring the enzyme transketolase (TK); this enzyme is typically measured indirectly (i.e., measuring the thiamine-dependent activity of the enzyme transketolase). Decreased levels of thiamine are used for diagnosis of vitamin B1 deficiency (a disease called beriberi); they are typically found in diets low in thiamine, chronic alcoholism, or some inborn metabolic diseases.
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