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  • Immunoassay reagents intended to perform qualitative and/or quantitative analyses on a body fluid sample (e.g., serum) to determine antibodies directed against thyroid peroxidase (TPO), the main and possibly only antigenic component of the thyroid epithelial cells. Antibodies against TPO (i.e., anti-TPO antibodies) provide a high sensitivity and specificity for microsomal antibodies of thyroid epithelial cells; anti-TPO antibodies are found in almost all adult patients with a progressive autoimmune disease of the thyroid gland with lymphocytic infiltration (Hashimoto\'s thyroiditis), in more than 80% of patients with Grave\'s disease, and in patients with idiopathic myxedema (associated with primary hypothyroidism). Reagents for anti-TPO are used for detecting, confirming, and monitoring autoimmune thyroid disorders.
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