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  • Immunoassay reagents intended to perform qualitative and/or quantitative analyses on a body fluid sample (e.g., serum) to determine antinuclear antibodies to centromere proteins (CENP). Increased circulating levels of CENP are found in CREST variant scleroderma and in some patients with Raynaud\'s disease and other autoimmune diseases (e.g., polymyositis, systemic lupus erythematosus).
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