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  • Immunoassay reagents intended to perform qualitative and/or quantitative analyses on a body fluid sample (e.g., whole blood, bile, feces) to determine protoporphyrin IX, a porphyrin derivative that is usually called heme when it contains iron. Protoporphyrin is not water soluble and is not excreted in urine. Its determination usually requires whole blood and/or erythrocyte assays; analysis of protoporphyrin in feces also has diagnostic capabilities. High levels of protoporphyrin are found in toxic (acquired) porphyrias caused by one or more of a group of toxic agents (e.g., lead, aluminum in dialysis). Some dietary products, metabolic diseases, and hereditary deficiencies (i.e., inherited porphyrias) may also cause abnormal protoporphyrin levels.
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