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  • Immunoassay reagents intended to perform quantitative analyses on a body fluid sample (e.g., serum, plasma) to measure the level of quinidine, an optical isomer of quinine, present in the sample. Quinidine dampens the excitability of cardiac and skeletal muscles by blocking sodium and potassium currents across cellular membranes. It prolongs cellular action potential, and decreases automaticity. Quinidine also blocks muscarinic and alpha-adrenergic neurotransmission. Quinidine drug level tests are used in the treatment/monitoring of certain cardiovascular conditions (e.g., atrial premature contraction, tachycardia). Quinidine is available either as quinidine sulfate or quinidine gluconate. These reagents are used to measure quinidine levels in patients, e.g., to determine the adequacy of therapy, and in the diagnosis of a drug overdose or drug-related toxicity.
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