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Immunoassay reagents intended to perform qualitative and/or quantitative analyses on a body fluid sample (typically urine) to determine a fraction (known as NTx) of the amino-terminal telopeptide that originates from one of the two intermolecular sites of the pyridinoline cross-linking with type I collagen. Increased levels of NTx are strongly associated with bone-resorption (NTx is a sensitive bone resorption marker) in osteoporosis and other bone diseases.
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