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  • Immunoassay reagents intended to perform qualitative and/or quantitative analyses on a body fluid sample (e.g., blood) to determine calcitonin, a hormone normally secreted by the C cells of the thyroid, as a tumor marker. Calcitonin is usually secreted to decrease the calcium release from bone, thus lowering the calcium level in serum. High levels of calcitonin are associated with medullar carcinoma of the thyroid; their level in serum correlates with tumor progress and metastases. Determination of the level of calcitonin is also used for screening of inherited familial medullar carcinoma of the thyroid. High levels of calcitonin are also found in other malignancies (e.g., lung, breast, and renal cancer) and sometimes in nonmalignant diseases (e.g., pancreatitis, pernicious anemia).
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