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  • Hematology reagents used to determine the time required for thrombin to convert fibrinogen to an insoluble fibrin clot when fibrin formation is triggered by the addition of ecarin (a snake venom) to the specimen. This test does not measure deficiencies in the intrinsic or extrinsic pathways of coagulation; the test is only intended to measure the levels of recombinant hirudin (lepirudin), a direct thrombin inhibitor anticoagulant that is frequently used in cardiac surgery and as a general antithrombotic agent.
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