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  • Immunology reagents including monoclonal antibodies that are used in immunologic tests for typing T lymphocytes by identifying their antigens (e.g., CD2, CD3, CD4, CD8). Frequently cells bearing the CD4+ receptor are termed helper cells and those with the CD8+ receptor are termed suppressor T cells. T-lymphocytes are typically associated with cellular immunity and are also involved in humoral immunity. These tests permit the differentiation between polyclonal processes and monoclonal neoplasms and also contribute in the classification among different types of lymphoid neoplasms. The ratio of CD4+/CD8+ is used in the diagnosis and monitoring of AIDS; an increase in this ratio is also considered an early indicator in the diagnosis of transplanted organ rejection.
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