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  • Immunoassay reagents intended to perform quantitative analyses on a body fluid sample (e.g., serum, plasma) to measure the levels of one or more of a group of therapeutic drugs that have the capacity to inhibit the growth of or to kill other microorganisms (i.e., antibiotics) present in the sample. Antibiotics (e.g., amikacin, gentamicin) sufficiently nontoxic to the host are administered to humans for treatment of infectious diseases typically caused by bacteria. These reagents are typically used in tests intended to measure the drug levels in patients undergoing treatment, either to determine the adequacy of drug treatment or diagnose a drug overdose or antibiotic-related toxicity. Samples drawn late in the drug administration interval, e.g., immediately prior to the next dose (known as a \'trough\' sample) and/or samples drawn within a set interval based on the known half-life of the drug (e.g., within 1 hour) following the administration of a dose (known as a \'peak\' sample) are typically used when measuring therapeutic levels of antibiotic drugs in the blood.
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