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  • Immunoassay reagents intended to perform qualitative and/or quantitative analyses of a sample of body fluids (e.g., serum, urine) to determine C-peptide, a connecting (C) peptide chain that is removed when pro-insulin is cleaved to form insulin. C-peptide levels are better indicators of the beta cells function of the islets of Langerhans in the pancreas than insulin concentration because it is not extracted by the liver. C-peptide provides a useful index of insulin secretion in patients when insulin cannot be measured or is difficult to measure due to the presence of insulin antibodies. C-peptide determinations are also used to monitor patients with surgical resectomy of the pancreas and/or after pancreas transplant. Analysis of C-peptide is a better indicator of beta-cell function than peripheral insulin concentration; C-peptide tests do not measure exogenous insulin and do not cross-react with insulin antibodies. These tests are not used as general diagnosis criteria of diabetes mellitus.
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