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  • Human MKRN1 wild-type allele is located in the vicinity of 7q34 and is approximately 27 kb in length. This allele, which encodes E3 ubiquitin-protein ligase makorin-1 protein, plays a role in post-translational protein ubiquitination. A fusion of this gene and the BRAF gene may be associated with pilocytic astrocytoma.
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