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  • A protein dimer containing two STING monomers. It binds cyclic purine di-nucleotides. Activation of the sting complex by 2\',5\'-3\'-5\'-cyclic GMP-AMP activates nuclear transcription factor kB (NF-kB) and interferon regulatory factor 3 (IRF3) which then induce transcription of the genes encoding type I IFN and cytokines active in the innate immune response. [GOC:bhm, PMID:22705373, PMID:23706668, PMID:23910378]
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