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  • An orally available antagonist of the nociceptin receptor opioid receptor like -1 (ORL-1), with potential analgesic activity. Upon oral administration, cebranopadol binds to ORL-1 and prevents its interaction with nociceptin. This leads to a decrease of nociceptin/ORL-1-mediated signaling and interferes with the sensation of pain, which results in an analgesic effect. Nociceptin is a neuropeptide involved in the regulation of pain. Check for \'https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C112002\' active clinical trials using this agent. (\'http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C112002\' NCI Thesaurus)
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