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  • A fusion gene that results from a chromosomal translocation t(3;21)(q28;q22) which fuses either the 5\' untranslated region or the 5\' end including exons 1 and 2 of the TMPRSS2 gene with exon 2 of the ETV5 gene. This rearrangement is associated with prostate carcinoma and androgen-dependent expression of this fusion gene results in overexpression of ETS translocation variant 5 protein activity.
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