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  • Biomarker increase (B-type natriuretic peptide (BNP)/ N-terminal pro-BNP (NT-proBNP)) consistent with decompensation of heart failure (such as BNP greater than 500 pg/mL or NT-proBNP greater than 2,000 pg/mL). In patients with chronically elevated natriuretic peptides, a significant increase above baseline is required. (Hicks KA, Tcheng JE, Bozkurt B, Chaitman BR, Cutlip DE, Farb A, Fonarow GC, Jacobs JP, Jaff MR, Lichtman JH, Limacher MC, Mahaffey KW, Mehran, R, Nissen SE, Smith EE, Targum SL. 2014 ACC-AHA Key Data Elements and Definitions For Cardiovascular Endpoint Events In Clinical Trials: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Data Standards (Writing Committee to Develop Cardiovascular End Points Data Standards) J Am Coll Cardiol 2014; In Press)
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