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  • Molecular assay reagents intended to identify deletions or duplications of the cytochrome P450 family 2 subfamily D member 6 (CYP2D6) gene, located at chromosome 22q13.1, which encodes the protein cytochrome P450 2D6. The protein encoded by this gene is involved in drug metabolism and genetic variants at this locus have been associated with altered response to various drugs including amitriptyline, codeine, desipramine, doxepin, fluvoxamine, imipramine, nortriptyline, paroxetine, selective serotonin reuptake inhibitors (SSRIs), tamoxifen, and trimipramine.
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