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  • An agonistic antibody that recognizes the co-stimulatory receptor OX40 (CD134;TNFRSF4), with potential immunostimulatory activity. Upon administration, anti-OX40 antibody PF-04518600 selectively binds to and activates OX40; which induces proliferation of memory and effector T-lymphocytes. In the presence of tumor-associated antigens (TAAs), this may promote a T-cell-mediated immune response against TAA-expressing tumor cells. OX40, a cell surface glycoprotein and member of the tumor necrosis factor receptor superfamily (TNFRSF), is expressed on T-lymphocytes and plays an essential role in T-cell activation. Check for \'https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C121927\' active clinical trials using this agent. (\'http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C121927\' NCI Thesaurus)
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