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  • A subtype of high risk B cell acute lymphoblastic leukemia (ALL) in which patients have a gene-expression profile similar to that of BCR-ABL1 positive ALL, but who all lack the BCR-ABL1 fusion gene. Similar to patients with BCR-ABL1 positive ALL, patients with Ph-like ALL frequently harbor alterations in lymphoid transcription factors. This is clinically important because of the presence of kinase-activating alterations that are amenable to treatment with currently available tyrosine kinase inhibitors. This subtype occurs in 10-15% of pediatric ALL patients and increases in frequency with age.
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