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  • A DNA-dependent helicase and 3\'-5\' exonuclease. It has 3\'->5\' exonuclease activity towards double-stranded DNA with a 5\'-overhang and binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and HOLLIDAY JUNCTIONS. Mutations in the WRN gene are associated with WERNER SYNDROME.
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