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  • Androgen receptor protein that is missing the amino acids encoded by exons 5-7 and part of the 5\' end of exon 8 of the human AR gene. This variant protein contains nuclear receptor transcriptional activation and DNA binding domains and is missing the nuclear receptor ligand binding and activation function-2 domains. Expression of this variant is associated with a gain-of-function phenotype and may be associated with prostate cancer.
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