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Molecular assay reagents intended to identify gene variants associated with Paget disease of bone, a bone disorder in which excessive bone remodeling leads to disorganized bone structure and increased susceptibility to skeletal fractures. Genetic variants at multiple loci have been associated with Paget disease of bone. These reagents are intended to detect various types of genetic changes (e.g., deletions, duplications, insertions, single nucleotide polymorphisms) in multiple Paget disease of bone-associated loci simultaneously.
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