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Molecular assay reagents intended to identify deletions or duplications of the HER2/NEU gene, located at chromosome 17q12, which encodes the protein receptor tyrosine-protein kinase erbB-2. Genetic variants at this locus have been associated with susceptibility to glioma and response to the drugs pertuzumab and trastuzumab. Somatic mutations in HER2 have been observed in breast, gastric, and lung cancers.
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