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  • Molecular assay reagents intended to identify mutations in the major histocompatibility complex, class I, B (HLA-B) gene, located at chromosome 6p21.3, which encodes the major histocompatibility complex class I antigen HLA-B heavy chain. Genetic variants at this locus have been associated with increased risk of ankylosing spondylitis and hypersensitivity to various drugs including abacavir, allopurinol, and carbamazepine.
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