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  • An increase in anti-human leukocyte antigen (anti-HLA) mostly seen in chronic renal failure patients that have undergone haemodialysis and polytransfusion. Other factors leading to anti-HLA hyperimmunisation are renal transplantation and pregnancy. Anti-HLA hyperimmunisation is a major factor in acute graft rejection. It can be limited by administrating erythropoietin for the treatment of chronic renal failure related anaemia, which reduces the number of transfusions required.
  • An increase in anti-human leukocyte antigen (anti-HLA) mostly seen in chronic renal failure patients that have undergone hemodialysis and polytransfusion. Other factors leading to anti-HLA hyperimmunization are renal transplantation and pregnancy. Anti-HLA hyperimmunization is a major factor in acute graft rejection. It can be limited by administrating erythropoietin for the treatment of chronic renal failure related anemia, which reduces the number of transfusions required.
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