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  • Human BCAR4 wild-type allele is located in the vicinity of 16p13.13 and is approximately 9 kb in length. This allele, which encodes breast cancer anti-estrogen resistance 4 long non-coding RNA, plays a role in both metastasis and antiestrogen resistance in breast carcinoma. Focal amplification and chromosomal rearrangement involving the gene may be associated with cervical cancer.
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