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  • One of 6 forms of the TNFd microsatellite repeat, which consists of three regions containing the repetitive dinucleotide sequence, (GA)n, each separated by a single diguanine repeat and is located 15 kb downstream of the TNF gene in intron 3 of the LST1 gene. TNFd3 three repeat regions contain 13 GA repeats, 9 GA repeats and 3 GA repeats, respectively. The TNFd3 polymorphism may influence tumor necrosis factor protein expression and may be associated with increased susceptibility to either inflammatory diseases or post-transplant complications.
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