?:definition
|
-
Human APOL1 wild-type allele is located in the vicinity of 22q12.3 and is approximately 15 kb in length. This allele, which encodes apolipoprotein L1 protein, plays a role in the metabolism of cholesterol and other lipids. Variation of the gene is associated increased susceptibility to both focal segmental glomerulosclerosis 4 and non-diabetic end-stage renal disease.
|