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Multimodal assay reagents intended to determine whether a patient exhibits homologous repair deficiency (HRD) by assessing multiple HRD markers: loss of heterozygosity (LOH), telomeric-allelic imbalance (TAI), and large-scale state transitions (LST). These multimodal assays incorporate the results of these tests into a predetermined algorithm that produces a score intended to aid clinicians in determining disease diagnosis, prognosis, and/or treatment options.
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