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  • Vascular closure devices that utilize an absorbable nonthrombogenic sealant intended to close the arteriotomy (or venous puncture). They are designed to be percutaneously applied to an arterial puncture (arteriotomy) and/or venous puncture site, e.g., using a guide wire and delivery device. Once in place, these sealants are designed to expand and conform to the arteriotomy or venous puncture site. They achieve hemostasis by tamponading the puncture site. These sealants are typically positioned in the extravascular space over the arteriotomy (or venous puncture) site; some designs may incorporate an intravascular component.
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