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Human NPPA wild-type allele is located in the vicinity of 1p36.22 and is approximately 3 kb in length. This allele, which encodes natriuretic peptides A, plays a role in the regulation of natriuresis, diuresis, and vasodilation. Mutation of the gene is associated with atrial fibrillation familial type 6 and atrial standstill type 2.
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