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  • An immune checkpoint inhibitor with potential immunomodulating and antineoplastic activities. Although the exact target is undisclosed, ASP8374 inhibits the activity of an immune checkpoint protein, which ultimately leads to the activation of a cytotoxic T-lymphocyte (CTL)-mediated immune response against cancer cells. Check for \'https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C141421\' active clinical trials using this agent. (\'http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C141421\' NCI Thesaurus)
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