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  • A preparation of ex vivo expanded, autologous CD4 and CD8 positive antigen presenting T cells (T-APCs), genetically modified with a transgene encoding a truncated form of human cluster of differentiation 19 (CD19t), with potential immunostimulating activity. Upon infusion, autologous CD19t-expressing T-APCs may stimulate the proliferation and activation of preadministered therapeutic CD19-targeted chimeric antigen receptor T cells (CAR-T). This may both improve the persistence of the therapeutic CAR-T cells and prevent relapse in patients with CD19 positive leukemia or lymphoma. CD19 is a B-cell specific cell surface antigen that is expressed in all B-cell lineage malignancies. Check for \'https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C142205\' active clinical trials using this agent. (\'http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C142205\' NCI Thesaurus)
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