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  • A controlled-release tablet formulation containing the hydrochloride salt of the aminoketone bupropion, with antidepressant activity and for potential use in promoting smoking cessation and improving sexual desire. Bupropion is a weak blocker of the neuronal uptake of serotonin, dopamine and norepinephrine and is a central nicotinic acetylcholine receptor antagonist. The controlled-release formulation results in a higher concentration of the drug in the body over an extended period of time, thereby permitting a reduction in the frequency of dosing
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