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  • Molecular assay reagents intended to determine the sequence of nucleotides composing the variable region of mature B-cell or T-cell receptor genes following completion of VDJ recombination in immune cells. VDJ recombination is responsible for the generation of immune cell receptor diversity during immune cell maturation, and creates a genetic sequence unique to each B- or T-cell clone. Identification and/or detection of this unique genetic sequence may be used in the diagnosis and/or monitoring of diseases involving clonal expansion of immune cells such as leukemias, lymphomas, and other hematologic malignancies.
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