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  • A radioconjugate consisting of Sgc8, a 41 oligonucleotides long single-stranded DNA aptamer and protein tyrosine kinase-7 (PTK7; colon carcinoma kinase-4; CCK4)-targeting ligand, linked via the bi-functional agent 1,4,7-triazacyclononane-1,4,7-triacetic acid (NOTA), to the beta-emitting radioisotope gallium Ga 68, with potential imaging activity during positron emission topography/computed tomography (PET/CT). Upon administration of gallium Ga 68-NOTA-Sgc8, the Sgc8 aptamer moiety targets and binds to PTK7 expressed on certain tumor cells. Upon PET/CT imaging, this radioconjugate can be used to detect and quantify PTK7-expressing tumor cells. PTK7, a member of the receptor tyrosine kinase (RTK) superfamily, is overexpressed in many different tumor cell types and plays an important role in tumor cell proliferation, migration and invasion.
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