|
?:definition
|
-
Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to infection. Sepsis is caused by an infection of any organisms including bacterial, fungal and viral agents. In patients with an intact immune system, gram-positive and gram-negative bacteria are the most common cause. In patients with a compromised immune system, uncommon bacterial and fungal species are more commonly the cause. Many factors increase the risk of developing sepsis including indwelling vascular catheters or other invasive devices, recent surgical procedures, diabetes mellitus, cirrhosis, and compromised immune systems. Common sites of infection include the urinary, biliary, and gastrointestinal tracts as well as the lungs. Clinical signs are often non-specific but may include signs of infection including fever, tachycardia, and diaphoresis. As the condition deteriorates, signs and symptoms consistent with end-organ damage can present. Diagnosis of sepsis requires a combination of clinical signs and symptoms along with positive cultures of blood, urine or other sites of infection. Control of the infectious source should be undertaken promptly. All invasive devices should be removed or changed if possible; necrotic tissue and abscesses should be addressed. Treatment of sepsis centers on broad-spectrum antibiotics and supportive treatment with vasopressors, IV fluids, oxygen, and corticosteroids. Patients with septic shock generally require intensive care. Blood sugar control is critical for patients with diabetes as hyperglycemia will impede the ability to respond adequately to the infection.
|
![[This page as RDF]](https://research.tib.eu/covid-19/static/rdf-icon.gif){kind=icon}