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  • A term that refers to clinicopathologic, cytogenetic, and molecular findings that define a myeloma as high risk. They include: ISS (International Staging System) stage III, elevated LDH, t(4;14), del(17/17p), t(14;16), t(14;20), hypodiploidy, gain(1q), and gene expression profile with high risk signature in which several genes are mapped to chromosome 1(q) and (1p).
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