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  • A contrast agent formulation composed of a polymeric core containing the paramagnetic contrast agent manganese chloride tetrahydrate (MnCl2 4H2O), in which the Mn2+ ions are chelated to phosphonate groups, and covered with a coating layer of covalently attached polyetyleneglycol (PEG)-polymers, that can potentially be used as a contrast enhancer during magnetic resonance imaging (MRI). Upon intravenous administration of the nanoparticle-based manganese-containing contrast agent SN132D, the nanoparticles enhance absorption of the poorly absorbable contrast agent manganese, and selectively accumulates in the tumor microenvironment (TME). Due to the retention of manganese in the TME and its paramagnetic properties, this contrast agent enhances the visualization and detection of tumor cells during MRI.
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