PropertyValue
?:definition
  • An immunotherapeutic agent that targets both CD19 and 4-1BB (CD137; tumor necrosis factor receptor superfamily member 9; TNFRSF9), with potential immunostimulatory and antineoplastic activity. Upon administration, CD19-targeted 4-1BB ligand RO7227166 simultaneously binds to CD19 and 4-1BB, thereby crosslinking CD19 and 4-1BB positive cells. This triggers, through the 4-1BB ligand, the proliferation and activation of natural killer cells (NKs) and T-cells. This results in an enhanced cytotoxic T-lymphocyte (CTL)-mediated immune response against CD19-expressing tumor cells. 4-1BB, a surface glycoprotein of the tumor necrosis factor receptor superfamily (TNFRSF), is an inducible costimulatory receptor that plays a key role in T-cell proliferation, survival and cytolytic activity.
?:hasCUIAnnotation
?:hasGeneratedBy
?:type

Metadata

Anon_0  
<http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/net/provenance/ns#DataItem>
<http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://www.w3.org/2004/03/trix/rdfg-1/Graph>
<http://xmlns.com/foaf/0.1/primaryTopic> <https://research.tib.eu/covid-19/entity/C5239344_NCI>
<http://xmlns.com/foaf/0.1/topic> Anon_0
<http://www.ontologydesignpatterns.org/cp/owl/informationrealization.owl#realizes> <https://research.tib.eu/covid-19/data/entity/C5239344_NCI>
<http://purl.org/net/provenance/ns#createdBy>
Anon_1   (more)
expand all