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  • A recombinant human adenoviral (rAd)-based vaccine encding for the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) spike glycoprotein (SP), with potential immunomodulating and anti-COVID-19 activities. Gam-COVID-Vac contains two components: a rAd type 26 (rAd26) prime component encoding the SARS-CoV-2 S protein gene and a rAd type 5 (rAd5) boost component encoding the SARS-CoV-2 S protein gene. Upon intramuscular administration of the Gam-COVID-Vac, the Ad infects cells and produces SP. The released SP activates the immune system to induce a humoral and cell-mediated immune response against SARS-CoV-2. This may prevent SARS-CoV-2 infection and inhibit viral replication. SP, usually found on the surface of SARS-CoV-2, plays an essential role in the infection pathway of the SARS-CoV-2 virus.
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