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  • A humanized immunoglobulin (Ig) G1 monoclonal antibody against the human cytokine granulocyte macrophage colony-stimulating factor (GM-CSF), with potential anti-inflammatory and immunomodulating activities. Upon administration, TJ-003234 binds to and neutralizes GM-CSF. This prevents GM-CSF binding to the GM-CSF receptor and prevents GM-CSF-mediated signaling, thereby inhibiting inflammatory responses mediated by macrophages, neutrophils, and dendritic cells and reducing inflammation and tissue damage. GM-CSF plays a key role in the differentiation and proliferation of monocytes, macrophages and granulocytes. Elevated levels of GM-CSF are associated with certain autoimmune diseases, inflammatory diseases, and cancers.
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